06 Jun

GoodGut abre una ronda de financiación en Capital Cell para ultimar su test de cáncer colorrectal

GoodGut abre una ronda de financiación en Capital Cell para ultimar su test de cáncer colorrectal


GoodGut celebra su quinto aniversario con varios hitos empresariales, médicos y científicos logrados. Con la mirada puesta en finalizar la validación clínica del RAID-CRC, el primer test no invasivo para el diagnóstico precoz del cáncer colorrectal a partir de la microbiota intestinal, la empresa biotecnológica acaba de poner en marcha una ampliación de capital de 400.000 euros. Los pequeños inversores, médicos, pacientes y sociedad en general pueden acceder con tickets a partir de 500 euros en la plataforma especializada en salud Capital Cell.

Desde su creación en 2014, de la mano de Jesús García-Gil, Xavier Aldeguer y Mariona Serra, GoodGut ha conseguido tener tres productos con marcado CE: RAID-Dx, test diagnóstico no invasivo para el Síndrome del Intestino Irritable (SII); RAID-Monitor, test no invasivo para monitorizar la actividad de la EII (EII), y TestUrGut, un test no invasivo que permite conocer la microbiota intestinal.

También ha obtenido la licencia de fabricante de producto de diagnóstico in vitro otorgada por la Agencia Española del Medicamento y Producto Sanitario (AEMPS) y la certificación del sistema de calidad ISO 13485.

Recientemente, GoodGut ha firmado un acuerdo de distribución con Palex Medical, empresa líder en productos de diagnóstico in vitro en enfermedades digestivas en España y Portugal.

Mariona Serra, CEO de la compañía, explica que “damos la oportunidad a sumarse a este impulso final que nos permitirá entrar en el valioso mercado del producto de diagnóstico in vitro y hacer que la detección precoz de las enfermedades digestivas esté al alcance de todos“.

A lo largo de estos años, GoodGut ha levantado financiación por más de 2,5 millones de euros de Caixa Capital Risc, el Instituto Catalán de Finanzas, así como la Comisión Europea y el Ministerio de Economía y Competitividad español a través de programas competitivos del H2020 y RETOS por la innovación.

23 Apr

GoodGut signs an agreement with Palex to launch first non-invasive diagnostic tests for IBS and IBD

GoodGut signs an agreement with Palex to launch first non-invasive diagnostic tests for IBS and IBD

GoodGut has signed an agreement with Palex Medical to start selling its new non-invasive diagnostic tests RAID-Dx for irritable bowel syndrome (IBS) and RAID-Monitor for inflammatory bowel disease (IBD) in Spain.

These are the first products developed by GoodGut to reach the patient after ten years of R&D and clinical validation with internationally prestigious digestive system researchers and gastroenterologists. They are all based on patented technology that detects a specific strain of bacteria for each of the pathologies in a faeces sample.

The system provides significant benefits for the medical community and patients. RAID-Dx is the first tool that can be used for a fast and reliable diagnosis of IBS, which until now could only be diagnosed by excluding other pathologies, and also offers a differential diagnosis from IBD. RAID-Monitor meanwhile can be used to detect IBD and carry out monitoring that significantly improves patients’ quality of life.

GoodGut was created in 2014 to introduce a new global paradigm into the clinical standards for digestive diseases. “This agreement with a leading firm like Palex Medical and starting to sell our products is a real step forward“, says Mariona Serra, co-founder and CEO of GoodGut. “We are proud that knowledge generated in academia with the doctors Xavier Aldeguer and Jesús Gil has turned into new medical solutions for society”, she tells us.

“We feel very fortunate to have been able to work with GoodGut in making this innovative technology offering clinicians new tools for improving patients’ quality of life accessible to clinical laboratories and gastroenterologists”, says Montse Carenys, director of the In Vitro Diagnosis and Oncology Division at Palex Medical.

Palex Medical is Spain’s leading company in the field of diagnosing and monitoring IBD. As a result of the agreement reached with GoodGut, Palex Medical has been able to include diagnostic tools that are unique to the market in its portfolio.

Almost half of all Spaniards suffer from a digestive pathology according to the Spanish Digestive System Foundation. To prevent the occurrence of diseases of this type from increasing, it is important to encourage the population to adopt healthy habits and to develop new medical solutions for prevention and early stage diagnosis. IBS is one of the ten most difficult diseases to identify according to the Fleming list and in the case of IBD it is estimated that up to 45% of patients wait for over a year for diagnosis, and 17% for over five years.

Currently GoodGut has five products in development in the pipeline (four non-invasive diagnostic tests and a prebiotic).

Photo: From left to right, Montse Carenys (Palex), Xavier Vengochea (Palex), Mariona Serra (GoodGut), Jaume Clarina (Palex), Juan Manuel Garcia (Palex) and Dr Xavier Aldeguer (GoodGut).

In the media:

06 Dec

Mariona Serra receives the Fidem award for innovation

Mariona Serra receives the Fidem award for innovation

The co-founder and CEO of GoodGut, Mariona Serra, was honoured with the Fidem 2018 award for innovation at a gala held on 29 November in CaixaFòrum Barcelona. Serra received the award from the Catalan Minister of the Presidency, Elsa Artadi, who took part in the event alongside the Minister of Enterprise and Knowledge, Àngels Chacón.

For the last 21 years, the International Foundation for Women Entrepreneurs (Fidem) has through this award recognised successes and initiatives by women who, through good management of their businesses, contribute to economic and social development. “These women are pioneers in their speciality and will become a reference for future generations” explained Joana Amat, president of Fidem.

“I was delighted to receive this recognition as women are well represented within GoodGut, not only in management but also the scientific team. It was a very exciting award. It is important to continue to raise the profile of women in the world of business and entrepreneurship” said Mariona Serra.

Fidem also recognised the talent of seven other businesswomen, entrepreneurs and executives: Therese Jamaa, General Manager of GSMA Mobile World Capital; Angie Rosales, director of Pallapupas; Inka Guixà, Chief Executive of La Farga; Àngels Roqueta, founding partner of Compas Private Equity; Aina Juliol, CEO of PGI Engineering; Emília Vila, co-founder and CEO of Agroptima, and Mireia Banega, founder of Eya Bach.

News in the press:


26 Oct

Gebro Pharma and Goodgut unite to advance the treatment of Crohn’s disease

Gebro Pharma and Goodgut unite to advance the treatment of Crohn’s disease

Gebro Pharma and Goodgut have come together to explore, by means of a clinical trial, whether or not variations in the composition of intestinal flora influence patients’ response to treatment for inflammatory bowel disease (IBD) in order to define these bacterial markers as a parameter for predicting which patients will respond best.

It is estimated that IBD currently affects around 2.2 million people in Europe and approximately 120,000 in Spain, with the incidence of the disease rising globally. The existing treatments not only have a high cost and significant side effects, but are effective in only 60% of patients, of whom around 50% end up becoming non-responsive to the treatment.

Recent studies indicate that the bacterial communities present in the colon mucosa of a patient with Crohn’s disease, ulcerative colitis or irritable bowel syndrome (IBS) are structurally different from those of healthy individuals.

The University Hospital Doctor Josep Trueta in Girona is participating in the trial, led by Dr Xavier Aldeguer, Head of the Digestive Tract Department at the hospital, and Lecturer in Digestive Physiology at the University of Girona Faculty of Medicine. Other team members include Mariona Serra, Goodgut CEO and pharmacologist, and Bellvitge University Hospital, with the collaboration of Dr Jordi Guardiola, Head of its Digestive Tract Department.

The growing role of intestinal microbiota

In recent years the role of microbiota has gradually become clearer, and studies on the matter have become increasingly common due to the relevance and impact that resident bacteria in physiology and pathology have on human health.

The main functions of intestinal microbiota include metabolic activities, that is, the recovery of energy and nutrients, and protection of the individual against invasion by foreign micro-organisms. Intestinal bacteria also play an essential role in developing and modulating the immune system, meaning that alterations to the balance of these bacterial species have significant repercussions involving microflora in multiple pathological processes, not only in the gastrointestinal tract, as in IBD or colon cancer, but in the whole organism.

With bacterial flora having been described as an agent triggering the pathogenesis of IBD, the effectiveness of the treatment of said diseases could be subject to differences in its composition. In fact, around 30% of the patients do not respond to treatment have intestinal dysbiosis (imbalance or impoverishment); it appears that this factor means that a higher degree of dysbiosis means a lower response to the treatment.

03 Oct

GoodGut conducts a clinical trial at Beth Israel Deaconess Medical Center in Boston

GoodGut conducts a clinical trial at Beth Israel Deaconess Medical Center in Boston

GoodGut and the Beth Israel Deaconess Medical Center (BIDMC) in Boston are collaborating on a clinical trial to validate the RAID-CD test for diagnosing inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). The study is being led by Dr Alan Moss, gastroenterologist at the prestigious centre and associate professor at Harvard Medical School.

Dr Moss has taken an interest in the test being developed by Goodgut due to the contribution it will make to innovating healthcare systems: it is a non-invasive test which for the first time offers a positive diagnosis for IBS and differential diagnosis for IBD. RAID-CD will help to reduce the direct costs generated by the incorrect diagnosis of these bowel diseases, and the waiting time for patients suffering from the diseases. It is also more reliable than current systems as it is based on a specific biomarker in a stool sample.

The BIDMC Inflammatory Bowel Disease Centre is one of the most active in researching these diseases in the United States, while Dr Moss’s translational research group is focused on faecal biomarkers, vitamin D as immunomodulator and intestinal microbiota as therapeutic goal.

In September GoodGut’s researcher Joan Amoedo visited the centre as the company’s representative to monitor the trial and process patient samples.

It is calculated that 50 million people around the world are affected by IBD, Crohn’s disease and ulcerative colitis, with diagnosis tending to be slow and based on vague clinical parameters. IBS meanwhile is one of the 10 most difficult diseases to identity according to Fleming’s list.

17 Apr

Doctor Julià Panés joins the GoodGut Board of Advisors

Doctor Julià Panés joins the GoodGut Board of Advisors

GoodGut has a new member of its Board of Advisors: Dr Julià Panés, a well-known specialist in inflammatory bowel disease (IBD). Panés is the director of the IBD research group at the August Pi i Sunyer Biomedical Research Institute (Idibaps) and head of the IBD Unit at Barcelona’s Hospital Clínic. His team publishes an average of 20 scientific articles a year in prestigious journals such as the New England Journal of Medicine, Lancet and Gastroenterology

Panés has had an illustrious career: over 300 publications, 500 conference speeches and membership of global gastroenterology organisations such as the American Gastroenterological Association (AGA), United European Gastroenterology (UEG), European Chron’s and Colitis Organisation (ECCO) and International Organization for the Study of Inflammatory Bowel Diseases (IOIBD). He is also a lecturer at the University of Barcelona. In 2013 he received the Award for Professional Excellency from the Barcelona College of Doctors (Col·legi de Metges).

Panés is the fourth member of GoodGut’s Board of Advisors, alongside the doctors Antoni Castells and Fermín Mearin, and the entrepreneur Gabriel Masfuroll.

GoodGut is developing various non-invasive tests based on intestinal microbiota for early diagnosis of digestive diseases, such as RAID-CD for IBD and irritable bowel syndrome.

16 Feb

The GoodGut colon cancer test, one of the projects to be supported by the CIMTI

The GoodGut colon cancer test, one of the projects to be supported by the CIMTI

The Centre for the Integration of Medicine and Innovative Technologies (CIMTI), created in 2017 at the initiative of the Leitat Foundation with the support of the Catalan Department of Health and the Agency for Health Quality and Assessment of Catalonia, has selected GoodGut’s RAID-CRC test as one of the health innovation projects that will improve patient quality of life.

The RAID-CRC test is a non-invasive method which will be used to prevent and diagnose colorectal cancer more effectively and reduce the need for unnecessary colonoscopies. Positive results from the first clinical trial were recently published.

The projects supported by the CIMTI are in the development phase and have been selected “with great care, focusing on those which may have a significant overall impact on health and which are viable” explained Manel Balcells, director of the centre.

The CIMTI has a collaboration agreement with the CIMIT in Boston, one of the most important centres in the world for medical innovation and on which the CIMTI is modelled.

All of the projects selected which are already up and running were launched by public hospitals and the CIMTI will now support them to find further funding: “There are already private investors interested in funding these projects, and the CIMTI acts as an intermediary”, Balcells told us. In the case of GoodGut, a 4 million euro funding round has been opened to bring the new test to the market before the end of 2019.

For further information read the following news items on Ara (in Catalan) and La Vanguardia (in Spanish) websites.

19 Jan

GoodGut does trials on more effective test to prevent colon cancer

GoodGut does trials on more effective test to prevent colon cancer

GoodGut has presented positive results for the RAID-CRC test which will improve early detection of colorectal cancer (CRC). This test yields 55% fewer false positives than screening with faecal occult blood tests, as blood is not a specific marker of CRC and, as a result, limits the number of colonoscopies that must be given.

These conclusions are from a multi-centre study with 450 patients with symptoms pointing to CRC who had had a colonoscopy at five Catalan hospitals that are leaders in oncology: Dr Josep Trueta University Hospital, Bellvitge University Hospital, Catalan Institute of Oncology, Healthcare Institute (IAS) and the Hospital Consortium of Vic.

Currently, the main colon-cancer screening programme in many countries is the immunochemical faecal occult blood test (FIT–Kit OC-Sensor®). This test is effective and affordable, but has a low positive predictive value (8%), which means it yields a high percentage of false positives leading to unnecessary colonoscopies. RAID-CRC complements the current screening with the microbiological signature of CRC in the faecal sample.

“The results of the study prove that screening with RAID-CRC and FIT detects CRC with up to 94% sensitivity and advanced neoplasms with 80% sensitivity,” explains Dr Xavier Aldeguer, GoodGut medical director and head of the Digestive System Department at Dr Josep Trueta University Hospital in Girona. Aldeguer has been researching the intestinal microbiota for more than 10 years.

Furthermore, Dr Antoni Castells, co-coordinator of the Barcelona colorectal cancer detection programme, says the new approach would “reduce the number of unnecessary colonoscopies by 32% and detect 59% of precancerous lesions“. The savings associated with colonoscopies alone would add up to more than €5.5 million per round of screening every two years and increase the sensitivity to detect precancerous lesions (diagnosing the disease in a very early stage).

Third most common form of cancer in the world

CRC is the third most common form of cancer in occurrence and mortality rate in the world, according to the World Health Organisation (WHO). Each week, more than 8,600 new cases of colon cancer are diagnosed in Europe and 2,500 in the United States. This is why population screening policies have been implemented to detect the disease early with non-invasive tools.

Using RAID-CRC “will have a significant positive impact on society, as the current screening system is more diagnostic than preventative,” says Mariona Serra, CEO of GoodGut. Serra also explains that the next step is validating these results in a larger sample of patents and after will allow the company to get CE marking for the test and take it to market by the end of 2019.

10 Oct

GoodGut moves to new premises at Science and Technology Park of Girona

GoodGut moves to new premises at Science and Technology Park of Girona

GoodGut has moved to a new space at Science and Technology Park of Girona: equipped with the latest technology, such as class II biosafety cabinets, it makes for easier interaction among the team of scientists and business development professionals.

This change comes at a key moment for the biotechnology company, which is getting ready to present the clinical results of its pipeline of non-invasive systems for improving early diagnosis of colon cancer, Crohn’s disease and ulcerative colitis, among other inflammatory bowel diseases (IBD). GoodGut is aiming to have these products on the market by 2019.

GoodGut was created in 2014 as a spin-off of University of Girona and Biomedical Research Institute of Girona Dr Josep Trueta by Mariona Serra, Xavier Aldeguer and Jesús Garcia-Gil. “It is very important to us to work in a scientific and business environment in a city as attractive as Girona and be at the heart of an internationally-recognised life sciences cluster like the BioRegion of Catalonia” says Mariona Serra, CEO of the company. Today there are over 140 companies, research groups and institutions based at the UdG Park.

10 Oct

GoodGut launches a new website with its digestive health pipeline

GoodGut launches a new website with its digestive health pipeline

Digestive diseases have a high incidence rate and have a chronic and serious impact on the daily life of sufferers. GoodGut has just launched a new website (www.goodgut.eu), with the slogan Enhancing Digestive Health, on which it presents its pipeline of non-invasive and prebiotic systems for improving the diagnosis and treatment of conditions including colon cancer, Crohn’s disease, and ulcerative colitis. These products are in the clinical trial phase, with plans for them tol be put on the market in 2019.

This intuitive new website provides the user with full corporate information: the company; mission, vision and values; Management and Board of Advisers; strategic and scientific partners; social responsibility, and a page dedicated to careers.

It also includes two update sections: the latest news from the company and a blog to disseminate knowledge of the research and development of GoodGut and digestive diseases in general.

Innovation based on intestinal microbiota

GoodGut’s know-how is based on the study of the intestinal microbiota of individuals, a determining factor in the immune system of the intestine and the development of digestive diseases. The company offers pioneering technological solutions for obtaining a faster, more reliable and cheaper medical diagnosis than using existing methods, and treatments to improve the quality of life of patients with compromised digestive health.

GoodGut was created in 2014 as a spin-off of University of Girona and Biomedical Research Institute of Girona Dr Josep Trueta by Mariona Serra, Xavier Aldeguer and Jesús Garcia-Gil. The company is based in the Science and Technology Park of Girona and forms part of CataloniaBio, the Catalan association of health and life sciences companies.